<br> The President of the United States issues different types of documents, together with but not limited to; memoranda, notices, determinations, letters, messages, and orders. 5F-MDMB-PICA is a designer drug and artificial cannabinoid. In 2018, it was the fifth-most widespread synthetic cannabinoid identified in medication seized by the Drug Enforcement Administration.<br><br> <br><br>5F-EDMB-PINACA is a designer drug and synthetic cannabinoid. In , it was the fourth-most widespread artificial cannabinoid recognized in drugs seized by the Drug Enforcement Administration. Any person who handles , or who needs to handle, 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA or FUB-144 is required to be registered with DEA to conduct such actions pursuant to 21 U.S.C. 822, 823, 957, and 958 and in accordance with 21 CFR component<br><br>