<br> <br><p>Herein we report on twelve circumstances with proven 5F-MDMB-PICA consumption, together with three fatalities, four cases of driving underneath the influence of drugs and five different legal acts. In these cases, 5F-MDMB-PICA was detected in postmortem blood or serum. In and urine samples, the hydrolysis metabolite of 5F-MDMB-PICA may be detected.</p><br><br> <br><br><br><br> <br><p>•Hydrolysis metabolites of artificial cannabinoids could be found in serum samples. Linking in vitro and ex vivo CB1 activity with serum concentrations and scientific features in 5F-MDMB-PICA customers to better perceive SCRAs and their metabolites. MDMB-4en-PINACA (also incorrectly generally known as 5-CL-ADB-A) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.</p><br><br> <br><br><br><br> <br><h2>Nms Labs</h2><br><br> <br><br><br><br> <br><p>Metabolic profili</p><